Scientific activities

Scientific activities

Workshops and Conferences to come (1)

Seminars to come (2)

Past Workshops and Conferences (5)

Past Seminars (60)

Workshops and Conferences
(to come)

CAMBAM Workshops

En ligne / Online
July 27 – August 27, 2020

Frédéric Guichard (McGill University)
Anmar Khadra (McGill University)
Web Link :

Seminars (to come)

Friday, August 14, 2020 – 12:30 – 13:30
Seminar CAMBAM Seminar Series
En ligne/Web – Veuillez contacter l’organisateur / Please contact the organizer:

A Mathematical Framework for Modelling the Metastatic Spread of Cancer

Mark Chaplain, University of St. Andrews – Vidéoconférence

Invasion and metastasis are two of the hallmarks of cancer and are intimately connected processes. Invasion, as the name suggests, involves cancer cells spreading out from the main cancerous mass into the surrounding tissue, through production and secretion of matrix degrading enzymes. Metastatic spread is the process whereby invasive cancer cells enter nearby blood vessels (or lymph vessels), are carried around the body in the main circulatory system and then succeed in escaping from the circulatory system at distant secondary sites where the growth of the cancer starts again. It is this metastatic spread that is responsible for around 90% of deaths from cancer. To shed light on the metastatic process, we present a mathematical modelling framework that captures for the first time the interconnected processes of invasion and metastatic spread of individual cancer cells in a spatially explicit manner—a multigrid, hybrid, individual-based approach. This framework accounts for the spatiotemporal evolution of mesenchymal- and epithelial-like cancer cells, membrane-type-1 matrix metalloproteinase (MT1-MMP) and the diffusible matrix metalloproteinase-2 (MMP-2), and for their interactions with the extracellular matrix. Using computational simulations, we demonstrate that our model captures all the key steps of the invasion-metastasis cascade, i.e. invasion by both heterogeneous cancer cell clusters and by single mesenchymal-like cancer cells; intravasation of these clusters and single cells both via active mechanisms mediated by matrix-degrading enzymes (MDEs) and via passive shedding; circulation of cancer cell clusters and single cancer cells in the vasculature with the associated risk of cell death and disaggregation of clusters; extravasation of clusters and single cells; and metastatic growth at distant secondary sites in the body.

Friday, August 28, 2020 – 12:30 – 13:30
Seminar CAMBAM Seminar Series
En ligne/Web – Veuillez contacter l’organisateur / Please contact the organizer:

Modeling the Innate Immune Cells

Angela Reynolds, Virginia Commonwealth University – Vidéoconférence

During an inflammatory response there is a complex cascade of reactions, which may lead to health or sustained inflammation during many diseases and processes, such as wound healing and infections. In order to understand how the immune cells involved in the inflammatory response contribute to the disease progression, we have developed various models for the immune cell dynamics. In this talk we will start by analyzing a reduced model and then adapting this model to various diseases by increasing the complexity of the immune cells in the model to gain more biological insight. Using bifurcations, parameter estimation, and sensitivity analysis, we will explore predictors of outcome and how modulating the immune response dynamics can alter patient outcome.

Workshops and Conferences

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Date Title Venue Participants
2015/06/01 – 2015/06/12 The Joint 2015 CAMBAM-MBI-NIMBioS Summer School / Nonlinear Dynamics in Biological Systems McGill University 50
2017/06/12 – 2017/06/14 Translational-Oriented Quantitative Theurapeutic Approaches: A Concerted Effort Université de Montréal 9
2018/06/18 – 2018/06/29 The Joint CAMBAM/NSERC-CREATE in Complex Dynamics Summer School McGill University 58
2019/07/15 – 2019/07/19 Summer School on Nonlinear Dynamics in Life Sciences Fields Institute
2020/06/05 – 2020/06/05 CAMBAM Zoomposium: Multiple Timescales in Neuronal and Other Systems En ligne / Online


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Date Speaker Title Type
2014/09/04 Michael Mackey, McGill University Deterministic Brownian motion Séminaire CAMBAM
2014/09/11 Jesse Vincent-Herscovici, MITACS Business Development Part 1: Canadian innovation / Part 2: Prospecting 101, finding (and influencing) a prospective partner Séminaire CAMBAM
2014/09/18 Majid Jaberi-Douraki, McGill University Predictive Models of Type 1 Diabetes Progression: Modeling Cyclic Waves of Circulating T Cells Séminaire CAMBAM
2014/09/25 Morgan Craig, Université de Montréal A physiologically-based model of granulopoiesis to guide dosing regimens in oncology Séminaire CAMBAM
2014/10/02 Alejandro Rey, McGill University Device Model of Outer Hair Cells Séminaire CAMBAM
2014/10/09 Svetlana Komarova, McGill University Mechanosensitivity and mechanotrasnduction in bone cells Séminaire CAMBAM
2014/10/16 Frédéric Guichard, McGill University Biogeochemical cycles across ecological networks

Séminaire CAMBAM
2014/10/23 Spencer Moran, McGill University A conductance-based model for burst firing in GnRH neurons Séminaire CAMBAM
2014/10/30 Theo Zanos, McGill University A sensorimotor role for traveling waves in primate visual cortex Séminaire CAMBAM
2014/11/13 Leon Glass, McGill University Evolution and Robustness in Gene Networks Séminaire CAMBAM
2014/11/20 Greg Stacey, McGill University The wireless brain – an oscillator network model of neural field effects

Séminaire CAMBAM
2014/11/27 Tony Humphries, McGill University Modelling myelopoiesis with differential equations Séminaire CAMBAM
2014/12/04 Lea Popovic, Concordia University Stochastic effects in intracellular reactions Séminaire CAMBAM
2015/01/08 François Grégoire-Lacoste, Université de Montréal Canard explosion and mixed mode oscillations in a gating subsystem of a ventricular ionic model Séminaire CAMBAM
2015/01/15 Nedialko Krouchev, Université de Montréal A Model Of Primary and Artificial Visual Networks Activation Séminaire CAMBAM
2015/01/22 Ashkan Golzar, McGill University The functional link between neural activity and behavior in a motion-correlation detection task Séminaire CAMBAM
2015/01/29 Thomas Quail, McGill University Spatial Symmetry Breaking Determines Spiral Wave Chirality

Séminaire CAMBAM
2015/02/05 Jacques Bélair, Université de Montréal A model of malaria transmission between groups Séminaire CAMBAM
2015/02/12 Siamak Salavatian, Université de Montréal Analysis of neuronal activity in right atrium ganglionated plexus in relation to atrial fibrillation Séminaire CAMBAM
2015/02/19 Stéphanie Portet, University of Manitoba Modelling intermediate filaments Séminaire CAMBAM
2015/02/22 Craig Benham, UC Davis Genome Center Topologically Driven Structural Transitions in DNA – Their Analysis and Roles in Regulation Séminaire CAMBAM
2015/02/26 Tina Mitre, McGill University Dynamics of galactose-regulated gene network and metabolic consumption in yeast Séminaire CAMBAM
2015/03/05 Ridouan Bani, McGill University TBA Séminaire CAMBAM
2015/03/05 Jay Potharst, Boston University 2015-CAMBAM Séminaire CAMBAM
2015/03/12 Drew Zhang, McGill University Memory and bistability in excitable media Séminaire CAMBAM
2015/03/19 Xiaotian Wu, Université de Montréal TBA Séminaire CAMBAM
2015/03/26 Laurent MacKay Allosteric regulation of the purinergic P2X receptors Séminaire CAMBAM
2015/04/02 Michael R. Guevara Lillie’s Iron-Wire Model of Nerve: Origin and Developments Séminaire CAMBAM
2015/04/09 Alan Cohen, Université de Sherbrooke TBA Séminaire CAMBAM
2015/05/24 Anmar Khadra, McGill University What can mathematical models tell us about autoimmune type 1 diabetes? Séminaire CAMBAM
2016/09/22 Leah Keshet, UBC Pattern formation and cell polarization models Séminaire CAMBAM
2016/09/29 Laurent Mackay, McGill University Systematic Analysis of Transient intracellular Calcium Signs in Live Cells Séminaire CAMBAM
2016/10/06 Lois Boullu, Lyon A delay-differential equation with state-dependent delay for megakaryopoiesis Séminaire CAMBAM
2016/10/13 Ahmad Haider, McGill Modelling and Computer Simulations for the Assessment of Artificial Pancreas Systems Séminaire CAMBAM
2016/10/20 Michael Mackey, McGill Open problems in the dynamics of differential delay equations Séminaire CAMBAM
2016/10/27 Mathieu Blanchette, McGill Know thy ancestors to know thyself: Improving our understanding of the human genome using paleogenomics Séminaire CAMBAM
2016/11/03 Mitchell Feigenbaum, Rockefeller University TBA Séminaire CAMBAM
2016/11/10 Sébastien Portalier, McGill University Physics, Body Size and the Structure of Food Webs Séminaire CAMBAM
2016/11/17 Paul François, McGill University Renormalizaton bilological networks based on their functions Séminaire CAMBAM
2016/11/24 Lucas Campanari, McGill University Patterns of activities in excitable media with channels Séminaire CAMBAM
2016/12/01 Allen Ehrlicher, McGill University Actin and the mechanical cell Séminaire CAMBAM
2016/12/08 Patricio Artusa, McGill University The role of T-cell repertoire diversity in CD4+T cell responses Séminaire CAMBAM
2016/12/15 Farzan Nadim, NJIT TBA Séminaire CAMBAM
2019/01/08 Ed Bullmore, Cambridge University TBD Séminaire CAMBAM Seminar Series
2019/01/15 Sabrina Leslie, McGill University TBD Séminaire CAMBAM Seminar Series
2019/01/22 Pierre-Andre Menard, Computer Research Institute of Montreal TBD Séminaire CAMBAM Seminar Series
2020/05/01 Claire Guerrier, Université Côte d’Azur (Vidéoconférence) Modeling axon-myelin relationships: insights on signal propagation and modulation Séminaire CAMBAM Seminar Series
2020/05/08 Roeland Merks, Mathematical Institute and Institute of Biology, Leiden University, The Netherlands (Vidéoconférence) Collective Cell Behavior and Cell Migration Séminaire CAMBAM Seminar Series
2020/05/15 Pouya Bashivan, Université de Montréal, MILA (Vidéoconférence) Analyze, Predict & Control: A Pragmatic Approach to Understanding the Visual Brain Séminaire CAMBAM Seminar Series
2020/05/22 Mathieu Desroches, Inria, Sophia Antipolis – Méditerranée Research Centre (Vidéoconférence) Slow-fast analysis of neural bursters: old and new Séminaire CAMBAM Seminar Series
2020/05/29 Yoichiro Mori, University of Pennsylvania (Vidéoconférence) Cell volume control and osmosis-driven cell movement Séminaire CAMBAM Seminar Series
2020/06/12 André Longtin, Université d’Ottawa – Vidéoconférence Gamma and Beta Burst Rhythms and E-I network inference Séminaire CAMBAM Seminar Series
2020/06/19 James Sneyd, University of Auckland – Vidéoconférence Modeling Calcium Signaling in Live Animals Séminaire CAMBAM Seminar Series
2020/06/26 Thomas Hillen, University of Alberta – Vidéoconférence Mathematical Modeling of the Immune-Mediated Theory of Metastasis Séminaire CAMBAM Seminar Series
2020/07/03 Carson Chow , National Institute of Diabetes and Digestive and Kidney Diseases – Vidéoconférence Global predictions of unreported SARS-CoV2 infection from observed COVID-19 cases Séminaire CAMBAM Seminar Series
2020/07/10 José Antonio Carrillo, University of Oxford – Vidéoconférence Attractive-repulsive models in collective behavior and applications Séminaire CAMBAM Seminar Series
2020/07/17 Sue Ann Campbell, University of Waterloo – Vidéoconférence Modulation of synchronization by a slowly varying M-current Séminaire CAMBAM Seminar Series
2020/07/24 Frithjof Lutscher, University of Ottawa – Vidéoconférence A seasonal hybrid model for the evolution of flowering onset in plants Séminaire CAMBAM Seminar Series
2020/07/31 Philip Maini, University of Oxford – Vidéoconférence Modelling collective cell movement in biology and medicine Séminaire CAMBAM Seminar Series
2020/08/07 Jonathan Rubin, University of Pittsburgh – Vidéoconférence Multiple roles of synaptic “inhibition” & how they arise in decision-making pathways in the basal ganglia Séminaire CAMBAM Seminar Series