Organisateurs/Organizers

Henri Darmon (Université McGill)
Jean-François Coeurjolly (UQAM)


Archives

Colloque de mathématiques CRM-ISM
2018-2019
2017-2018
2016-2017
2015-2016
2014-2015
2013-2014
2012-2013
2011-2012
2010-2011
2009-2010
2008-2009
2007-2008
2006-2007
2005-2006
2004-2005
2003-2004
2002-2003

Colloque de statistique CRM-ISM-GERAD
2013-2014
2012-2013
2011-2012
2010-2011
2009-2010
2008-2009

2019 - 2020

Calendrier / Calendar

MONTRÉAL



Date Heure/Time : Le vendredi 19 juin 2020 - 16:00

Lieu/Venue : Zoom meeting : https://umontreal.zoom.us/j/94839201651?pwd=Nm52ZzUzWjdrNWhlMG04Rk1Cb0NZQT09

Conférencier/Speaker : Morgan Craig, Université de Montréal - Vidéoconference

Titre/Title : Quantitative approaches to understanding the immune response to SARS-CoV-2 infection

Resume/Abstract :
COVID-19 is typically characterized by a range of respiratory symptoms that, in severe cases, progress to acute respiratory distress syndrome (ARDS). These symptoms are also frequently accompanied by a range of inflammatory indications, particularly hyper-reactive and dysregulated inflammatory responses in the form of cytokine storms and severe immunopathology. Much remains to be uncovered about the mechanisms that lead to disparate outcomes in COVID-19. Here, quantitative approaches, especially mechanistic mathematical models, can be leveraged to improve our understanding of the immune response to SARS-CoV-2 infection. Building upon our prior work modelling the production of innate immune cell subsets and the viral dynamics of HIV and oncolytic viruses, we are developing a quantitative framework to interrogate open questions about the innate and adaptive immune reaction in COVID-19. In this talk, I will outline our recent work modelling SARS-CoV-2 viral dynamics and the ensuing immune response at both the tissue and systemic levels. A portion of this work is done as part of an international and multidisciplinary coalition working to establish a comprehensive tissue simulator (physicell.org/covid19 [1]), which I will also discuss in more detail.