Chaire André Aisenstadt Chair 2007

Dr. John Tyson

(Virginia Polytechnic Institute & State University)


Une série de conférences / A series of lectures

Le samedi 22 septembre 2007 / Saturday, September 22, 2007

9 h 00 / 9:00 am

Conférence dans le cadre du mini-cours sur la biologie quantitative
Lecture within the minicourse on quantitative biology

Sniffers, Buzzers, Toggles and Blinkers

The reaction networks in living cells can often be decomposed into simple 'motifs' that perform recognizable functions, such as switches, oscillators and filters. Mathematical models of these motifs reveal their dynamical potentials, and permit the motifs to be joined together into computable representations of complex, realistic, accurate and predictive models of cell behavior.

Centre de recherches mathématiques
Université de Montréal
Pavillon André-Aisenstadt, 2920, chemin de la Tour
Salle / Room 6214


Le lundi 24 septembre 2007 / Monday, September 24, 2007

16 h 00 / 4:00 pm

Conférence André-Aisenstadt Lecture
Cette conférence s'adresse à un large auditoire. / Suitable for a general audience.

How Do Cells Compute?

The living cell is an information processing system that receives input from its external environment and internal state, computes an appropriate response to prevailing conditions, and issues instructions for alterations in gene expression, cell growth and division, movement, and (perhaps) programmed cell death. Information processing in the cell is carried out by a water-soluble gemisch of genes, proteins and metabolites that bears little resemblance to solid-state, digital computers. What are the basic principles by which cells receive and process information and orchestrate their life-or-death responses to a dangerous world? And how can mathematics help us to understand how cells compute?

Centre de recherches mathématiques
Université de Montréal
Pavillon André-Aisenstadt, 2920, chemin de la Tour
Salle / Room 1360 

Une réception suivra la conférence au Salon Maurice-l'Abbé,
Pavillon André-Aisenstadt (Salle 6245).
A reception will follow the lecture in Salon Maurice-l'Abbé,
Pavillon André-Aisenstadt (Room 6245).


Le vendredi 26 septembre 2007 / Friday, September 26, 2007

11 h / 11:00 am

Conférence dans le cadre de l’Atelier sur la décomposition des réseaux biochimiques
Lecture within the Workshop on Deconstructing Biochemical Networks

 

Cell Cycle Regulation in Eukaryotes

The eukaryotic cell cycle is regulated by a complex network of interacting genes and proteins. The dynamical properties of this network (and hence, the physiological properties of dividing cells) are governed by a set of nonlinear differential equations (reaction kinetic equations). The solutions of these equations are determined in large part by the bifurcations they exhibit: saddle-node bifurcations, Hopf bifurcations, and homoclinic bifurcations. One-parameter bifurcation diagrams are key to understanding how the cell cycle control machinery (based on cyclin-dependent kinases) coordinates cell division with overall cell growth, and two-parameter bifurcation diagrams provide a direct link from genetics to cell physiology.

Centre de recherches mathématiques, Université de Montréal
Pavillon André-Aisenstadt, 2920, chemin de la Tour
Salle / Room 6214


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