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This workshop will investigate the latest mathematical and computational approaches to the development of sophisticated biology-grounded sequence/genome evolution models, the latest evolutionary biology studies on the way in which selection imposes constraints and dependencies on sites, and the use of such models for the investigation of the function/structure of biological sequences. The participants will come from the fields of applied evolutionary biology, phylogenetics, genome evolution, protein/RNA structural biology, and population genetics, but will be expected to share a certain degree of mathematical sophistication.